ALCOHOL INHIBITS THE METABOLISM OF DIMETHYL FUMARATE TO THE ACTIVE METABOLITE RESPONSIBLE FOR DECREASING RELAPSE FREQUENCY IN THE TREATMENT OF MULTIPLE SCLEROSIS.

Dimethyl fumarate (DMF) is a first-line prodrug for the treatment of relapsing-remitting multiple sclerosis (RRMS) that is completely metabolized to monomethyl fumarate (MMF), the active metabolite, before reaching the systemic circulation.Its metabolism has been proposed to be due to ubiquitous esterases in the intestines and other tissues, but th

The total ozone content (TOC) values retrieved from measurements of spectral backscat- tered radiation with Total Ozone Mapping Spectrometer (TOMS) instruments onboard of Nimbus-7, Meteor-3 and Earth Probe platforms and with Ozone Monitoring Instrument (OMI) inboard of Aura platform are used to evaluate temporal and spatial distribution of statisti

Introduction The combination of biomarkers and drugs is the subject of growing interest both from regulators, physicians and companies.This study protocol of a systematic review is aimed to describe available literature evidences about the cost-effectiveness, cost-utility or net-monetary benefit of the use of biomarkers in solid tumour as tools for

Introduction: Paper-aided nursing documentation is cumbersome to navigate and requires large spaces for document storage.Electronic nursing process documentation solutions which are optimized to address paper-based documentation inefficiencies are limited in Nigerian hospitals.The Electronic Nursing Process Form (ENPF) is a digital nursing document

Thermal errors remain one of the biggest challenges for the precision of cutting machine tools.Aside from optimizations in the machine Candle Holder tool design and behaviour, optimal cutting process parameters and targeted usage of cutting fluid or alternative methods of tool cooling are required for improved process efficiency with minimal energy